β-Casein from milk

Typical Properties
CAS	9000-71-9
Catalog	ACM9000719-16
Molecular Weight	2061.96 g/mol
Melting Point	280 °C (dec.) (lit.)
Purity	≥70 %
Density	1.26 g/cm3
Solubility	H2O: insoluble, forms a cloudy suspension
Appearance	Powder
Storage	−20 °C
Biological Source	Bovine Milk
Color	white to off-white
Composition	≥98% (PAGE)
Grade	Reagent Grade
MDL Number	MFCD00130619
Quality Level	300
Shipping	Ambient
Solvent	Water
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.

Overview

Description

β-casein is a promising encapsulant for hydrophobic drug delivery. A specific area of interest is in targeted delivery and release of substances, such as mitoxantrone and paclitaxel, which are cytotoxic to tumor cells. In addition, the loading capacity of β-casein delivery vehicles for polyphenols is relatively high in comparison with other caseins. Hydrophobic substances are entrapped within β-casein micelles primarily through hydrophobic interactions, with β-casein due to its amphiphilic self-assembly, allowing increased bioavailability. Loading substances into β-casein micelles, which compose 15-50 molecules, is dependent on several factors, such as temperature, pH, solvent composition, ionic strength and critical micelle concentration.

Features

·Excellent water resistance
·Excellent fluidity
·Good machinability
·Strong dispersion
·Good biocompatibility

Application

·Protein substrates in proteolytic assays
·Polyacrylamide gel-embedded β-casein profiling
·As bioactive peptides, such as opiates, immunostimulants, antibacterial agents and generators of peptidase inhibitors