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Colloidal delivery systems help alleviate failures in optimizing molecular structures during drug development, so colloidal drug delivery is an increasingly important area of research that continues to deliver better medicines. Alfa Chemistry can screen and customize the most suitable colloidal delivery system for a specific application based on conditions such as route of administration, manufacturing complexity, storage stability and regulatory requirements. Our customized colloidal systems for drug delivery typically have submicron-scale structures, including micelles, nanoparticles, liposomes, dendrimers, and more.
Alfa Chemistry develops colloidal delivery systems to help customers encapsulate active pharmaceutical ingredients, improving their chemical stability and bioavailability.
Fig.1 A schematic of the various particle-based colloidal delivery systems.[1]
Our customization capabilities include but are not limited to:
Liposomes, as closed vesicles composed of bilayer lipid molecules with an aqueous phase inside, have the advantages of easy biodegradation, non-toxicity and non-immunogenicity, and are widely used in drug delivery systems. Alfa Chemistry masters a variety of liposome preparation methods and can customize various types of liposomes.
| Customized liposome types | Unilamellar liposomes, multilamellar liposomes, multivesicular liposomes, glycosyl-modified liposomes, thermosensitive liposomes, pH-sensitive liposomes, immunoliposomes, magnetic liposomes, etc. |
| Preparation | Thin-film dispersion method, reverse-phase evaporation method, solvent injection method, surfactant dispersion method, freeze-melt method, freeze-drying method, double emulsion method and active encapsulation method, etc. |
Nanoparticles are solid colloidal particles with a particle size of 1-1 000 nm made of natural or synthetic polymer materials. Alfa Chemistry can customize matrix spherical nanoparticles for drug adsorption and form nanocapsules by wrapping solid drugs or liquid drugs as capsule cores.
| Customized Nanoparticle types | Polylactic acid, polyglycolic acid, polylactic acid-glycolic acid copolymer, gelatin, chitosan, sodium alginate and other hydrophilic polymers. |
| Preparation | Polymerization reaction method, solvent evaporation method, salting out method, emulsification dispersion method and supercritical fluid method, etc. |
Alfa Chemistry enables the preparation of dendrimer drug delivery systems through a stepwise synthetic approach, where the drug is either covalently bound to the dendrimer surface or dissolved within a hydrophobic core or pocket within the dendrimer.
Fig.2 A schematic representation of a dendrimer-based therapeutic.[2]
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If you are interested in our Customized Colloid Delivery Systems, please don't hesitate to place an order now!
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