Gold-Citric Acid Colloidal Solution (Au, Purity: 99.9 %, Diameter:30nm)

Typical Properties
CAS	7440-57-5
Catalog	ACM7440575-178
Molecular Weight	196.97 g/mol
Boiling Point	2808 °C (lit.)
Melting Point	1063 °C (lit.)
Flash Point	4 °C
Purity	99.9 %
Density	19.3 g/mL at 25 °C (lit.)
Appearance	Colloidal Suspension
Storage	2-8 °C
Color	Light orange-Dark red
Composition	Au
Concentration	2-3 wt.% (Available as per Customer requirement)
Diameter	30 nm
pH	4
Precautions for use	According to different application fields, mix with other material systems according to the recommended dosage, and use it after fully stirring. ·For industrial catalysts, recommended dosage: ≥20ppm; ·For beauty and health care products, recommended dosage: ≥3ppm.
Quality Level	200
Shipping	Ambient Temperature
Solvent	Water

Overview

Description

Gold nanoparticles dispersion is to disperse gold nanoparticles into a solvent to form a neutral solution with stable and uniform color. The color of the solution is not golden yellow but red. If other substances are added to form a condensed state, the solution turns blue. The solution has the same antibacterial properties as nano silver, and also has better safety for human consumption and contact. Gold nanoparticles have been widely used due to their unique physical and optical properties.

Features

·Evenly dispersed, small particles
·Good compatibility, easy to disperse, easy to add a variety of systems
·Good system stability, reliable performance, safety and environmental protection
·High specific surface area, high loading, easy surface functionalization

Application

·Electronics: Gold nanoparticles are used as conductors in everything from printing inks to electronic chips.
·Photodynamic therapy: Gold nanoparticles (including nanoshells and nanorods) in the near-infrared absorption band generate heat when excited by light at wavelengths of 700 to 800 nm. This feature enables the nanoparticles to destroy targeted tumors.
·Therapeutic agent delivery: Therapeutic agents can be coated on the surface of gold nanoparticles.
·Sensors: Gold nanoparticles are used in various sensors.
·Diagnosis: Detection of Biomarkers
·Probes, catalysis, fuel cells

Case Study

Potential of Cystine/Citrate-Capped Gold Nanoparticles for Photothermal Cancer Therapy

Saw W S, et al. Colloids and Surfaces B: Biointerfaces, 2018, 161, 365-374.

The cellular uptake capability of gold nanoparticles (AuNPs) enables photothermal therapy (PTT) to achieve higher specificity for tumor treatment. The effect of different sizes of cystine/citric acid-coated confeito-like gold nanoparticles (confeito-AuNPs) on the PTT effect of MDA-MB231 breast cancer cells was studied. The results showed that AuNPs with a size of 30 nm had the highest cellular uptake rate through 2 endocytic pathways and exhibited the highest in vitro PTT efficacy.
Endocytic mechanisms of confeito-AuNPs
· The smallest confeito-AuNPs (30 nm) have the highest MDA-MB-231 cellular internalization via two endocytic mechanisms: clathrin- and caveolae-mediated pathways. Other sizes (60 nm, 80 nm and 100 nm) of confeito-AuNPs enter the cells through only the clathrin-mediated pathway.
· The intracellular localization of confeito-AuNPs is related to the cellular uptake pathway, and it is evidenced that all the sizes of confeito-AuNPs are highly localized in the lysosome due to the clathrinmediated pathway.
· Confeito-AuNPs (30 nm) have the highest localization in the endoplasmic reticulum compared with other sizes of confeito-AuNPs likely due to partial uptake via the caveolae-mediated pathway.
· In terms of photothermal treatment, confeito-AuNPs (30 nm) can increase the highest bulk temperature and display the highest photothermal cytotoxicity effect compared with other sizes of confeito-AuNPs.